Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk.

ABSTRACT:

Background

Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in gastric carcinogenesis. Single nucleotide polymorphisms (SNPs) in mitotic segregation genes could be responsible for inducing the slow process of accumulation of genetic changes, leading to genome instability.

Patients and methods

We performed a case-control study of polymorphisms in mitotic kinases TTK rs151658 and BUB1B rs1031963 and rs1801376 to assess their effects on gastric cancer risk. We examined the TTK abundance in gastric cancer tissues using immunoblot analysis.

Results

C/G genotype of rs151658 wa

SUBMITTER: Hudler P 

PROVIDER: S-EPMC5024654 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature