Development of Experimental Myopia in Chicks in a Natural Environment.

ABSTRACT:

Purpose

The hypothesis that outdoor exposure might protect against myopia has generated much interest, although available data find only modest clinical efficacy. We tested the effect of outdoor rearing on form-deprivation myopia in chicks, a myopia model markedly inhibited by high-intensity indoor laboratory lighting.

Methods

Unilaterally goggled cohorts of White Leghorn chicks were maintained in a species-appropriate, outdoor rural setting during daylight hours to the extent permitted by weather. Control chicks were reared indoors with incandescent lighting. Besides ocular refraction and ultrasound, we determined dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) content in retina and vitreous and measured mRNA expression levels of selected clock and circadian rhythm-rela

SUBMITTER: Stone RA 

PROVIDER: S-EPMC5024671 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature