Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population.

ABSTRACT:

Importance

Schizophrenia is a highly heritable, polygenic condition characterized by a relatively diverse phenotype and frequent comorbid conditions, such as anxiety and depression. At present, limited evidence explains how genetic risk for schizophrenia is manifest in the general population.

Objective

To investigate the extent to which genetic risk for schizophrenia is associated with different phenotypes during adolescence in a population-based birth cohort.

Design, setting, and participants

This cohort study used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Of 14,062 children in the birth cohort, genetic data were available for 9912 adolescents. Data were collected periodically from September 6, 1990, and collection is ongoing. Data were

SUBMITTER: Jones HJ 

PROVIDER: S-EPMC5024747 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature