Polymorphisms in the MTHFR gene are associated with recurrence risk in lymph node-positive breast cancer patients.

ABSTRACT:

Purpose

The aim of this study is to clarify the relationship between recurrence risk of breast cancer and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms.

Patients and methods

Breast cancer patients who had undergone surgery in Gaziantep University Oncology Hospital between June 2005 and June 2012 were followed-up and retrospectively enrolled in this study. Blood samples were collected from all patients to assess MTHFR C677T polymorphisms. Stage according to tumor-node-metastasis system, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 status, grade of disease, menopausal status, and administered chemotherapy or hormonal therapy were recorded. Effects of these parameters on recurrence risk were evaluated using univariate anal

SUBMITTER: Suner A 

PROVIDER: S-EPMC5024764 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature