MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis.

ABSTRACT: Animal African trypanosomosis is a major threat to the economic development and human health in sub-Saharan Africa. Trypanosoma congolense infections represent the major constraint in livestock production, with anemia as the major pathogenic lethal feature. The mechanisms underlying anemia development are ill defined, which hampers the development of an effective therapy. Here, the contribution of the erythropoietic and erythrophagocytic potential as well as of hemodilution to the development of T. congolense-induced anemia were addressed in a mouse model of low virulence relevant for bovine trypanosomosis. We show that in infected mice, splenic extramedullary erythropoiesis could compensate for the chronic low-grade type I inflammation-induced phagocytosis of senescent red blood cells (RB

SUBMITTER: Stijlemans B 

PROVIDER: S-EPMC5025191 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature