Mesenchymal Stem Cell Therapy for the Treatment of Vocal Fold Scarring: A Systematic Review of Preclinical Studies.

ABSTRACT:

Objectives

Therapy with mesenchymal stem cells exhibits potential for the development of novel interventions for many diseases and injuries. The use of mesenchymal stem cells in regenerative therapy for vocal fold scarring exhibited promising results to reduce stiffness and enhance the biomechanical properties of injured vocal folds. This study evaluated the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring.

Data sources

PubMed, Embase, the Cochrane Library and Google Scholar were searched.

Methods

Controlled studies that assessed the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring were included. Primary outcomes were viscoelastic properties and mucosal wave amplitude.

Res

SUBMITTER: Wingstrand VL 

PROVIDER: S-EPMC5025194 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature