Recent Advances in the Rational Design and Optimization of Antibacterial Agents.

ABSTRACT: This review discusses next-generation antibacterial agents developed using rational, or targeted, drug design strategies. The focus of this review is on small-molecule compounds that have been designed to bypass developing bacterial resistance, improve the antibacterial spectrum of activity, and/or to optimize other properties, including physicochemical and pharmacokinetic properties. Agents are discussed that affect known antibacterial targets, such as the bacterial ribosome, nucleic acid binding proteins, and proteins involved in cell-wall biosynthesis; as well as some affecting novel bacterial targets which do not have currently marketed agents. The discussion of the agents focuses on the rational design strategies employed and the synthetic medicinal chemistry and structure-based desig

SUBMITTER: Jones JA 

PROVIDER: S-EPMC5025264 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature