A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children's Oncology Group.

ABSTRACT:

Purpose

Neuroblastoma is a childhood cancer of the sympathetic nervous system with embryonic origins. Previous epidemiologic studies suggest maternal vitamin supplementation during pregnancy reduces the risk of neuroblastoma. We hypothesized offspring and maternal genetic variants in folate-related and choline-related genes are associated with neuroblastoma and modify the effects of maternal intake of folate, choline, and folic acid.

Methods

The Neuroblastoma Epidemiology in North America (NENA) study recruited 563 affected children and their parents through the Children's Oncology Group's Childhood Cancer Research Network. We used questionnaires to ascertain pre-pregnancy supplementation and estimate usual maternal dietary intake of folate, choline, and folic acid. We genot

SUBMITTER: Mazul AL 

PROVIDER: S-EPMC5025391 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature