Development of a prediction system for tail-anchored proteins.

ABSTRACT:

Background

"Tail-anchored (TA) proteins" is a collective term for transmembrane proteins with a C-terminal transmembrane domain (TMD) and without an N-terminal signal sequence. TA proteins account for approximately 3-5 % of all transmembrane proteins that mediate membrane fusion, regulation of apoptosis, and vesicular transport. The combined use of TMD and signal sequence prediction tools is typically required to predict TA proteins.

Results

Here we developed a prediction system named TAPPM that predicted TA proteins solely from target amino acid sequences according to the knowledge of the sequence features of TMDs and the peripheral regions of TA proteins. Manually curated TA proteins were collected from published literature. We constructed hidden markov models of TA protei

SUBMITTER: Shigemitsu S 

PROVIDER: S-EPMC5025589 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature