Chiral Antioxidant-based Gold Nanoclusters Reprogram DNA Epigenetic Patterns.

ABSTRACT: Epigenetic modifications sit 'on top of' the genome and influence DNA transcription, which can force a significant impact on cellular behavior and phenotype and, consequently human development and disease. Conventional methods for evaluating epigenetic modifications have inherent limitations and, hence, new methods based on nanoscale devices are needed. Here, we found that antioxidant (glutathione) chiral gold nanoclusters induce a decrease of 5-hydroxymethylcytosine (5hmC), which is an important epigenetic marker that associates with gene transcription regulation. This epigenetic change was triggered partially through ROS activation and oxidation generated by the treatment with glutathione chiral gold nanoclusters, which may inhibit the activity of TET proteins catalyzing the conversion o

SUBMITTER: Ma Y 

PROVIDER: S-EPMC5025748 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature