Ontology highlight
ABSTRACT:
SUBMITTER: Fiorenzano A
PROVIDER: S-EPMC5025790 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature communications 20160902
Known molecular determinants of developmental plasticity are mainly transcription factors, while the extrinsic regulation of this process has been largely unexplored. Here we identify Cripto as one of the earliest epiblast markers and a key extracellular determinant of the naive and primed pluripotent states. We demonstrate that Cripto sustains mouse embryonic stem cell (ESC) self-renewal by modulating Wnt/β-catenin, whereas it maintains mouse epiblast stem cell (EpiSC) and human ESC pluripotenc ...[more]