Improved 5-Factor Prognostic Classification of Patients Receiving Salvage Systemic Therapy for Advanced Urothelial Carcinoma.

ABSTRACT:

Purpose

Prognostic factors in patients receiving salvage systemic therapy for advanced urothelial carcinoma include performance status, liver metastasis, hemoglobin and time since chemotherapy. We investigated the impact of albumin, and neutrophil, lymphocyte and platelet counts.

Materials and methods

Patient level data from 10 phase II trials were used. Cox proportional hazards regression was applied to evaluate associations with overall survival. An optimal regression model was constructed using forward stepwise selection and risk groups were defined using the number of adverse factors. Trial was a stratification factor. External validation was done in a separate data set of 5 salvage phase II trials.

Results

Discovery data were obtained on 708 patients. After adjus

SUBMITTER: Sonpavde G 

PROVIDER: S-EPMC5025874 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature