Ontology highlight
ABSTRACT:
SUBMITTER: Jiang D
PROVIDER: S-EPMC5025885 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20160916
Activation of the IRE1α-XBP1 branch of the unfolded protein response (UPR) has been implicated in multiple types of human cancers, including multiple myeloma (MM). Through an in silico drug discovery approach based on protein-compound virtual docking, we identified the anthracycline antibiotic doxorubicin as an in vitro and in vivo inhibitor of XBP1 activation, a previously unknown activity for this widely utilized cancer chemotherapeutic drug. Through a series of mechanistic and phenotypic stud ...[more]