IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation.

ABSTRACT: The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge. However, these cells exhibit significant functional heterogeneity and the inflammatory signals that differentially influence their effector characteristics are poorly characterized. In this study, we defined the phenotype of discrete subsets of effective antigen-presenting cells (APCs) in the peritoneal cavity during peritonitis. When the functional properties of these cells were compared to inflammatory monocyte-derived macrophages we noted differential responses to the immune-modulatory cytokine IL-10. In contrast to the suppressive actions of IL-10 on inflammatory macrophages, the r

SUBMITTER: Liao CT 

PROVIDER: S-EPMC5026061 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature