Sickle Cell Trait, Rhabdomyolysis, and Mortality among U.S. Army Soldiers.

ABSTRACT:

Background

Studies have suggested that sickle cell trait elevates the risks of exertional rhabdomyolysis and death. We conducted a study of sickle cell trait in relation to these outcomes, controlling for known risk factors for exertional rhabdomyolysis, in a large population of active persons who had undergone laboratory tests for hemoglobin AS (HbAS) and who were subject to exertional-injury precautions.

Methods

We used Cox proportional-hazards models to test whether the risks of exertional rhabdomyolysis and death varied according to sickle cell trait status among 47,944 black soldiers who had undergone testing for HbAS and who were on active duty in the U.S. Army between January 2011 and December 2014. We used the Stanford Military Data Repository, which contains compreh

SUBMITTER: Nelson DA 

PROVIDER: S-EPMC5026312 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature