Human breast cancer biopsies induce eosinophil recruitment and enhance adjacent cancer cell proliferation.

ABSTRACT: Chronic inflammation is known to facilitate cancer progression and metastasis. Less is known about the effect of acute inflammation within the tumor microenvironment, resulting from standard invasive procedures. Recent studies in mouse models have shown that the acute inflammatory response triggered by a biopsy in mammary cancer increases the frequency of distal metastases. Although tumor biopsies are part of the standard clinical practice in breast cancer diagnosis, no studies have reported their effect on inflammatory response. The objective of this study is to (1) determine whether core needle biopsies in breast cancer patients trigger an inflammatory response, (2) characterize the type of inflammatory response present, and (3) evaluate the potential effect of any acute inflammatory res

SUBMITTER: Szalayova G 

PROVIDER: S-EPMC5026505 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature