Mitral valve endothelial cells secrete osteoprotegerin during endothelial mesenchymal transition.

ABSTRACT:

Aims

Mitral valve prolapse (MVP) has a prevalence of 3% in the general population, affecting >176 million people worldwide. Despite this, little is known about the molecular and cellular mechanisms involved in the progression of MVP and surgical intervention is the only available option. In this study we investigated the role of osteoprotegerin (OPG) during endothelial to mesenchymal transition (EndMT) in MVP.

Methods and results

VECs and VICs were isolated from posterior mitral valve leaflets of patients undergoing mitral valve repair (n=25). Plasma was collected from 57 subjects (29 controls and 28 MVP patients). Overexpression of OPG during EndMT followed by autocrine effects characterised by reactive oxygen species increment and accelerated migration was documented. In a

SUBMITTER: Songia P 

PROVIDER: S-EPMC5026583 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature