Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors.

ABSTRACT:

Rationale

We investigated aging of human endogenous reparative capacity and aimed to clarify whether it is affected by presence of cardiovascular disease or its risk factors (RFs).

Objective

Circulating progenitor cell (PC) levels reflect endogenous regenerative potential. The effect on PC of healthy aging compared with aging with RFs or cardiovascular disease (CVD) is unknown. We examined whether exposure to RF and CVD leads to an accelerated decline in circulating PC with increasing age.

Methods and results

In 2792 adult subjects, 498 were free of RFs (smoking, diabetes mellitus, hypertension, or hyperlipidemia), 1036 subjects had 1 to 2 RF, and 1253 had ≥3 RFs or CVD. PC were enumerated by flow cytometry as CD45(med+) mononuclear cells expressing CD34 and subsets c

SUBMITTER: Al Mheid I 

PROVIDER: S-EPMC5026592 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature