Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Rationale

Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but its use is limited by the need for parenteral administration. Nitrite can also be administered using a novel, portable micronebulizer system suitable for chronic use.

Objective

Determine whether inhaled nitrite improves hemodynamics in HFpEF.

Methods and results

In a double-blind, randomized, placebo-controlled, parallel-group trial, subjects with HFpEF (n=26) underwent cardiac catheterization with simultaneous expired gas analysis at rest and during exercise before and after treatment with inhaled sodium nitrite (90 mg) or placebo. Th

SUBMITTER: Borlaug BA 

PROVIDER: S-EPMC5026595 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature