CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema.

ABSTRACT:

Rationale and objectives

Many patients with chronic obstructive pulmonary disease (COPD) have marked discordance between forced expiratory volume in 1 second (FEV1) and degree of emphysema on computed tomography (CT). Biomechanical differences between these patients have not been studied. We aimed to identify reasons for the discordance between CT and spirometry in some patients with COPD.

Materials and methods

Subjects with Global initiative for chronic Obstructive Lung Disease stages I-IV from a large multicenter study (The Genetic Epidemiology of COPD) were arranged by percentiles of %predicted FEV1 and emphysema on CT. Three categories were created using differences in percentiles: Catspir with predominant airflow obstruction/minimal emphysema, CatCT with predominant emp

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC5026854 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature