Evaluating the dopamine hypothesis of schizophrenia in a large-scale genome-wide association study.

ABSTRACT:

Background

The dopamine hypothesis, which posits that dysregulation of the dopaminergic system is etiologic for schizophrenia, is among the most enduring biological theories in psychiatry. Although variation within genes related to dopaminergic functioning has been associated with schizophrenia, an aggregate test of variation, using the largest publicly available schizophrenia dataset, has not previously been conducted.

Methods

We first identified a core set of 11 genes involved in the synthesis, metabolism, and neurotransmission of dopamine. We then extracted summary statistics of markers falling within, or flanking, these genes from the Psychiatric Genomics Consortium's most recent schizophrenia mega-analysis results. We conducted aggregate tests for enrichment of dopamine

SUBMITTER: Edwards AC 

PROVIDER: S-EPMC5026897 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature