Effect of Lipopolysaccharide (LPS) Exposure on the Reproductive Organs of Immature Female Rats.

ABSTRACT: Lipopolysaccharide (LPS), an endotoxin, elicits strong immune responses in mammals. Several lines of evidence demonstrate that LPS challenge profoundly affects female reproductive function. For example, LPS exposure affects steroidogenesis and folliculogenesis, resulting in delayed puberty onset. The present study was conducted to clarify the mechanism underlying the adverse effect of LPS on the delayed puberty in female rats. LPS was daily injected for 5 days (50 μg/kg, PND 25-29) to treated animals and the date at VO was evaluated through daily visual examination. At PND 39, animals were sacrificed, and the tissues were immediately removed and weighed. Among the reproductive organs, the weights of the ovaries and oviduct from LPS-treated animals were significantly lower than those of con

SUBMITTER: Yoo da K 

PROVIDER: S-EPMC5027216 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature