Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse.

ABSTRACT: Genetic networks provide new mechanistic insights into the diversity of species morphology. In this study, we have integrated the MGI, GEO, and miRNA database to analyze the genetic regulatory networks under morphology difference of integument of humans and mice. We found that the gene expression network in the skin is highly divergent between human and mouse. The GO term of secretion was highly enriched, and this category was specific in human compared to mouse. These secretion genes might be involved in eccrine system evolution in human. In addition, total 62,637 miRNA binding target sites were predicted in human integument genes (IGs), while 26,280 miRNA binding target sites were predicted in mouse IGs. The interactions between miRNAs and IGs in human are more complex than those in mous

SUBMITTER: Wu J 

PROVIDER: S-EPMC5027296 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature