Ontology highlight
ABSTRACT:
SUBMITTER: Mirecka EA
PROVIDER: S-EPMC5027568 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20160919
In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of islet cell transplantation. Rational design of inhibitors of IAPP amyloid formation has therapeutic potential, but is hampered by the lack of structural information on inhibitor complexes of the conformationally flexible, aggregation-prone IAPP. Here we characterize a β-hairpin conformation of IAPP in complex with the engi ...[more]