Evolution of clinical features in possible DLB depending on FP-CIT SPECT result.

ABSTRACT:

Objective

To test the hypothesis that core and suggestive features in possible dementia with Lewy bodies (DLB) would vary in their ability to predict an abnormal dopamine transporter scan and therefore a follow-up diagnosis of probable DLB. A further objective was to assess the evolution of core and suggestive features in patients with possible DLB over time depending on the (123)I-FP-CIT SPECT scan result.

Methods

A total of 187 patients with possible DLB (dementia plus one core or one suggestive feature) were randomized to have dopamine transporter imaging or to follow-up without scan. DLB features were compared at baseline and at 6-month follow-up according to imaging results and follow-up diagnosis.

Results

For the whole cohort, the baseline frequency of parkinson

SUBMITTER: Walker Z 

PROVIDER: S-EPMC5027811 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature