Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood.

ABSTRACT:

Background

Innate immune responses are fine-tuned by small noncoding RNA molecules termed microRNAs (miRs) that modify gene expression in response to the environment. During acute infections, miRs can be secreted in extracellular vesicles (EV) to facilitate cell-to-cell genetic communication. The purpose of this study was to characterize the baseline population of miRs secreted in EVs in the airways of young children (airway secretory microRNAome) and examine the changes during rhinovirus (RV) infection, the most common cause of asthma exacerbations and the most important early risk factor for the development of asthma beyond childhood.

Methods

Nasal airway secretions were obtained from children (≤3 yrs. old) during PCR-confirmed RV infections (n = 10) and age-matched contro

SUBMITTER: Gutierrez MJ 

PROVIDER: S-EPMC5028059 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature