Metal oxide nanoparticles interact with immune cells and activate different cellular responses.

ABSTRACT: Besides cell death, nanoparticles (Nps) can induce other cellular responses such as inflammation. The potential immune response mediated by the exposure of human lymphoid cells to metal oxide Nps (moNps) was characterized using four different moNps (CeO₂, TiO₂, Al₂O₃, and ZnO) to study the three most relevant mitogen-activated protein kinase subfamilies and the nuclear factor kappa-light-chain-enhancer of the activated B-cell inhibitor, IκBα, as well as the expression of several genes by immune cells incubated with these Nps. The moNps activated different signaling pathways and altered the gene expression in human lymphocyte cells. The ZnO Nps were the most active and the release of Zn²⁺ ions was the main mechanism of toxicity. CeO

SUBMITTER: Simon-Vazquez R 

PROVIDER: S-EPMC5028082 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature