The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.

ABSTRACT: Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation res

SUBMITTER: Ju XC 

PROVIDER: S-EPMC5028191 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature