Characterization of erythropoietin and hepcidin in the regulation of persistent injury-associated anemia.

ABSTRACT:

Background

The cause of persistent injury-associated anemia is multifactorial and includes acute blood loss, an altered erythropoietin (EPO) response, dysregulation of iron homeostasis, and impaired erythropoiesis in the setting of chronic inflammation/stress. Hepcidin plays a key role in iron homeostasis and is regulated by anemia and inflammation. Erythropoietin is a main regulator of erythropoiesis induced by hypoxia. A unique rodent model of combined lung injury (LC)/hemorrhagic shock (HS) (LCHS)/chronic restraint stress (CS) was used to produce persistent injury-associated anemia to further investigate the roles of EPO, hepcidin, iron, ferritin, and the expression of EPO receptors (EPOr).

Methods

Male Sprague-Dawley rats were randomly assigned into one of the four group

SUBMITTER: Alamo IG 

PROVIDER: S-EPMC5028270 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature