Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions.

ABSTRACT:

Background & aims

Kupffer cells (KCs), the resident tissue macrophages of the liver, play a crucial role in the clearance of pathogens and other particulate materials that reach the systemic circulation. Recent studies have identified KCs as a yolk sac-derived resident macrophage population that is replenished independently of monocytes in the steady state. Although it is now established that following local tissue injury, bone marrow derived monocytes may infiltrate the tissue and differentiate into macrophages, the extent to which newly differentiated macrophages functionally resemble the KCs they have replaced has not been extensively studied.

Methods

We studied the two populations of KCs using intravital microscopy, morphometric analysis and gene expression profiling. An

SUBMITTER: Beattie L 

PROVIDER: S-EPMC5028381 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature