Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway.

ABSTRACT: In breast cancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that response to surgery may have a causative role. Radiotherapy (RT) after lumpectomy significantly reduces the risk of recurrence. We investigated the direct effects of surgery and of RT delivered intraoperatively (IORT), by collecting irradiated and non-irradiated breast tissues from BC patients, after tumor removal. These breast tissue specimens have been profiled for their microRNA (miR) expression, in search of differentially expressed miR among patients treated or not with IORT. Our results demonstrate that IORT elicits effects that go beyond the direct killing of residual tumor cells. IORT altered the wound response, inducing the expression of miR-223 in the peri-tumoral brea

SUBMITTER: Fabris L 

PROVIDER: S-EPMC5028421 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature