The rs2070895 (-250G/A) Single Nucleotide Polymorphism in Hepatic Lipase (HL) Gene and the Risk of Coronary Artery Disease in North Indian Population: A Case-Control Study.

ABSTRACT:

Introduction

Several Single Nucleotide Polymorphisms (SNPs) in lipid transport genes have been shown to be associated with Coronary Artery Disease (CAD). The Hepatic Lipase (HL)glycoprotein is a key component that catalyzes the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins.

Aim

We studied whether the HL gene-250G/A polymorphism affect blood lipid level and the CAD in a North Indian population.

Materials and methods

A total number of 477 subjects were enrolled in the study after approval of the Institutional Ethics Committee. Out of 477 subjects, 233 were with coronary artery disease as study group and 244 subjects without coronary artery disease as control group. All subjects recruited with matched ethnicity in age group of 40-70 y

SUBMITTER: Verma P 

PROVIDER: S-EPMC5028592 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature