Bcl-2 homologue Debcl enhances α-synuclein-induced phenotypes in Drosophila.

ABSTRACT:

Background

Parkinson disease (PD) is a debilitating movement disorder that afflicts 1-2% of the population over 50 years of age. The common hallmark for both sporadic and familial forms of PD is mitochondrial dysfunction. Mammals have at least twenty proapoptotic and antiapoptotic Bcl-2 family members, in contrast, only two Bcl-2 family genes have been identified in Drosophila melanogaster, the proapoptotic mitochondrial localized Debcl and the antiapoptotic Buffy. The expression of the human transgene α-synuclein, a gene that is strongly associated with inherited forms of PD, in dopaminergic neurons (DA) of Drosophila, results in loss of neurons and locomotor dysfunction to model PD in flies. The altered expression of Debcl in the DA neurons and neuron-rich eye and along with the

SUBMITTER: M'Angale PG 

PROVIDER: S-EPMC5028777 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature