Histomorphometric and ultrastructural analysis of the tendon-bone interface after rotator cuff repair in a rat model.

ABSTRACT: Successful rotator cuff repair requires biological anchoring of the repaired tendon to the bone. However, the histological structure of the repaired tendon-bone interface differs from that of a normal tendon insertion. We analysed differences between the normal tendon insertion and the repaired tendon-bone interface after surgery in the mechanical properties, histomorphometric analysis, and 3-dimensional ultrastructure of the cells using a rat rotator cuff repair model. Twenty-four adult Sprague-Dawley (SD) rats underwent complete cuff tear and subsequent repair of the supraspinatus tendon. The repaired tendon-bone interface was evaluated at 4, 8, and 12 weeks after surgery. At each time point, shoulders underwent micro-computed tomography scanning and biomechanical testing (N = 6), conven

SUBMITTER: Kanazawa T 

PROVIDER: S-EPMC5028779 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature