Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and Neonatal Rats.

ABSTRACT: Alteration of gut microbial colonization process may influence susceptibility of the newborn/infant to infectious and chronic disease. Infectious disease risk leads to widespread use of non-prescription antimicrobials in household products such as Triclocarban (TCC), an antimicrobial compound in personal care products. TCC concentrates in and is transferred through the milk to suckling offspring. TCC exposure during gestation and lactation significantly reduced phylogenetic diversity (PD) among exposed dams and neonates. Among dams using weighted UniFrac distances, TCC induced significant dysbiosis of gut microbiota by gestational day (GD) 18, a trend that continued after delivery. Similarly, an overall restructuring of gut microbiota occurred in neonates. By postnatal day (PND) 12, commun

SUBMITTER: Kennedy RC 

PROVIDER: S-EPMC5028839 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature