WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines.

ABSTRACT:

Background

Invasive lobular carcinoma (ILC) of the breast typically presents with clinical biomarkers consistent with a favorable response to endocrine therapies, and over 90 % of ILC cases express the estrogen receptor (ER). However, a subset of ILC cases may be resistant to endocrine therapies, suggesting that ER biology is unique in ILC. Using ILC cell lines, we previously demonstrated that ER regulates a distinct gene expression program in ILC cells, and we hypothesized that these ER-driven pathways modulate the endocrine response in ILC. One potential novel pathway is via the Wnt ligand WNT4, a critical signaling molecule in mammary gland development regulated by the progesterone receptor.

Methods

The ILC cell lines MDA-MB-134-VI, SUM44PE, and BCK4 were used to assess W

SUBMITTER: Sikora MJ 

PROVIDER: S-EPMC5028957 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature