Neonatal monocytes exhibit a unique histone modification landscape.

ABSTRACT:

Background

Neonates have dampened expression of pro-inflammatory cytokines and difficulty clearing pathogens. This makes them uniquely susceptible to infections, but the factors regulating neonatal-specific immune responses are poorly understood. Epigenetics, including histone modifications, can activate or silence gene transcription by modulating chromatin structure and stability without affecting the DNA sequence itself and are potentially modifiable. Histone modifications are known to regulate immune cell differentiation and function in adults but have not been well studied in neonates.

Results

To elucidate the role of histone modifications in neonatal immune function, we performed chromatin immunoprecipitation on mononuclear cells from 45 healthy neonates (gestational ag

SUBMITTER: Bermick JR 

PROVIDER: S-EPMC5028999 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature