Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, and has important health implications for mother and child. Changes in the fetoplacental vessels may predict those in the vasculature of the developing fetus, as these have been implicated in the pathogenesis of human GDM. This study aimed to determine the differences in the localization and expression level of VEGFA and VEGFR2 between placentas of women with GDM and placentas of normal pregnancies, which is the first step in elucidating the possible roles of VEGFA and VEGFR2 in the altered uteroplacental function resulting from maternal hyperglycaemia and ultimately in the manifestation of GDM.

Methods

The expressions of VEGFA and VEGFR2 mRNA and protein in 20 sample

SUBMITTER: Meng Q 

PROVIDER: S-EPMC5029036 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature