Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction.

ABSTRACT:

Background

Increased reactive oxygen species (ROS) production is involved in the process of adverse cardiac remodeling and development of heart failure after myocardial infarction (MI). NADPH oxidase-2 (Nox2) is a major ROS source within the heart and its activity increases after MI. Furthermore, genetic deletion of Nox2 is protective against post-MI cardiac remodeling. Nox2 levels may increase both in cardiomyocytes and endothelial cells and recent studies indicate cell-specific effects of Nox2, but it is not known which of these cell types is important in post-MI remodeling.

Methods and results

We have generated transgenic mouse models in which Nox2 expression is targeted either to cardiomyocytes (cardio-Nox2TG) or endothelial cells (endo-Nox2TG). We here studied the respo

SUBMITTER: Sirker A 

PROVIDER: S-EPMC5029266 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature