Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.

ABSTRACT:

Importance

The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of brain metabolism and atrophy as a proxy for understanding the underlying biology of the clinical effects of AC medications.

Objective

To assess the association between AC medication use and cognition, glucose metabolism, and brain atrophy in cognitively normal older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Indiana Memory and Aging Study (IMAS).

Design, setting, and participants

The ADNI and IMAS are longitudinal studies with cognitive, neuroimaging, and other data collected at regular i

SUBMITTER: Risacher SL 

PROVIDER: S-EPMC5029278 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature