Enhanced detection of respiratory pathogens with nanotrap particles.

ABSTRACT: The Influenza virus is a leading cause of respiratory disease in the United States each year. While the virus normally causes mild to moderate disease, hospitalization and death can occur in many cases. There are several methodologies that are used for detection; however problems such as decreased sensitivity and high rates of false-negative results may arise. There is a crucial need for an effective sample preparation technology that concentrates viruses at low abundance while excluding resident analytes that may interfere with detection. Nanotrap particles are hydrogel particles that are coupled to chemical dye affinity baits that bind a broad range of proteins and virions. Within minutes (<30 minutes), Nanotrap particles concentrate low abundant proteins and viruses from clinically comp

SUBMITTER: Shafagati N 

PROVIDER: S-EPMC5029303 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature