Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.

ABSTRACT:

Purpose

Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.

Methods

We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies.

Results

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC5029371 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature