An automated task for the training and assessment of distal forelimb function in a mouse model of ischemic stroke.

ABSTRACT:

Background

Behavioral models relevant to stroke research seek to capture important aspects of motor skills typically impaired in human patients, such as coordination of distal musculature. Such models may focus on mice since many genetic tools are available for use only in that species and since the training and behavioral demands of mice can differ from rats even for superficially similar behavioral readouts. However, current mouse assays are time consuming to train and score, especially in a manner producing continuous quantification. An automated assay of mouse forelimb function may provide advantages for quantification and speed, and may be useful for many applications including stroke research.

New method

We present an automated assay of distal forelimb function. In thi

SUBMITTER: Becker AM 

PROVIDER: S-EPMC5029438 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature