Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity.

ABSTRACT:

Objective

Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO).

Methods

Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), ∼5 years post-surgery, mean age 13.9 years. Four standard sections covering hypothalamic areas critical to energy homeostasis were used to assess lesions and calculate a hypothalamic lesion score (HLS); the association with HO was examined.

Results

Compared to subjects who did not develop HO (n = 23), subjects with HO (n = 22) showed more frequently lesions affecting the third ventricular

SUBMITTER: Roth CL 

PROVIDER: S-EPMC5029599 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature