Ontology highlight
ABSTRACT:
SUBMITTER: Amirouchene-Angelozzi N
PROVIDER: S-EPMC5029652 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Amirouchene-Angelozzi Nabil N Frisch-Dit-Leitz Estelle E Carita Guillaume G Dahmani Ahmed A Raymondie Chloé C Liot Géraldine G Gentien David D Némati Fariba F Decaudin Didier D Roman-Roman Sergio S Schoumacher Marie M
Oncotarget 20160401 17
Uveal melanoma (UM) is the most frequent malignant ocular tumor in adults. While the primary tumor is efficiently treated by surgery and/or radiotherapy, about one third of UM patients develop metastases, for which no effective treatment is currently available. The PKC, MAPK and PI3K/AKT/mTOR signaling cascades have been shown to be associated with tumor growth. However, none of the compounds against those pathways results in tumor regression when used as single agents. To identify more effectiv ...[more]