Clinicopathologic characteristics of EGFR, KRAS, and ALK alterations in 6,595 lung cancers.

ABSTRACT:

Background

EGFR, KRAS, and ALK alterations are major genetic changes found in non-small cell lung cancers (NSCLCs). Testing advanced lung adenocarcinoma tumors for these three genes is now standard care. The purpose of this study was to investigate the clinicopathologic expression pattern of these three genes in East Asian NSCLC patients.

Patients and methods

We conducted a retrospective study of all patients tested for mutations of these three genes at a single institute in Korea between 2006 and 2014. Study data were extracted from electronic medical records. Univariate and multivariate logistic regression analyses were used to measure associations between clinicopathologic features and alterations of EGFR, KRAS, and ALK.

Results

We detected 12 EGFR-mutated tumors w

SUBMITTER: Lee B 

PROVIDER: S-EPMC5029670 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature