An individualized prognostic signature and multi‑omics distinction for early stage hepatocellular carcinoma patients with surgical resection.

ABSTRACT: Previously reported prognostic signatures for predicting the prognoses of postsurgical hepatocellular carcinoma (HCC) patients are commonly based on predefined risk scores, which are hardly applicable to samples measured by different laboratories. To solve this problem, using gene expression profiles of 170 stage I/II HCC samples, we identified a prognostic signature consisting of 20 gene pairs whose within-sample relative expression orderings (REOs) could robustly predict the disease-free survival and overall survival of HCC patients. This REOs-based prognostic signature was validated in two independent datasets. Functional enrichment analysis showed that the patients with high-risk of recurrence were characterized by the activations of pathways related to cell proliferation and tumor mic

SUBMITTER: Ao L 

PROVIDER: S-EPMC5029687 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature