Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents.

ABSTRACT: A series of coordination gold(III), palladium(II), and platinum(II) complexes with a luminescent iminophosphorane ligand derived from 8-aminoquinoline [Ph₃P=N-C₉H₆N] (1), have been synthesized and structurally characterized. The coordination palladium(II) and platinum(II) compounds can evolve further, under appropriate conditions, to give stable cyclometalated endo species [M{κ³-C,N,N-C₆H₄(PPh₂=N-8-C₉H₆N}Cl] (M = Pd, Pt) by C-H activation of the phenyl group of the PPh ₃ fragment. Iminophosphorane 1 and the new metallic complexes are luminescent in DMSO or DMSO:H₂O (1:1 mixture) solutions at RT. The compounds have been evaluated for their antiprolife

SUBMITTER: Frik M 

PROVIDER: S-EPMC5029859 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature