Temporal Evolutionary Dynamics of Norovirus GII.4 Variants in China between 2004 and 2015.

ABSTRACT:

Background

Noroviruses are one of the major causes of acute human nonbacterial gastroenteritis, and genotype II.4 (GII.4) has accounted for the majority of adult outbreaks. In addition, novel epidemic strain emerges every 2 to 3 years and spreads globally in months. There are little data reporting the evolutionary dynamics of GII.4 variants along a specific period in China.

Methods

All norovirus GII.4 sequences in China were downloaded from GenBank Database. Phylogenetic tree was constructed by MEGA and Bayesian evolutionary inference techniques were applied by BEAST software to study the genetic relationships, evolution rate, evolutionary time scale and the demographic history of GII.4 variants. Homology models were predicted by SWISS-MODEL to analyze the spatial structure

SUBMITTER: Qiao N 

PROVIDER: S-EPMC5029875 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature