Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation.

ABSTRACT:

Background

Significant disruption in caregiving is associated with increased internalizing symptoms, most notably heightened separation anxiety symptoms during childhood. It is also associated with altered functional development of the amygdala, a neurobiological correlate of anxious behavior. However, much less is known about how functional alterations of amygdala predict individual differences in anxiety. Here, we probed amygdala function following institutional caregiving using very subtle social-affective stimuli (trustworthy and untrustworthy faces), which typically result in large differences in amygdala signal, and change in separation anxiety behaviors over a 2-year period. We hypothesized that the degree of differentiation of amygdala signal to trustworthy versus untrustwo

SUBMITTER: Green SA 

PROVIDER: S-EPMC5030125 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature